Stone and Parker co-wrote the songs in a 1999 South Park musical film
The creators of US animated comedy South Park are writing a musical stage comedy scheduled to premiere on Broadway in March 2011.
Trey Parker and Matt Stone have written the script, music and lyrics for The Book of Mormon with Robert Lopez, co-creator of musical Avenue Q.
It will tell the story of two young Mormon missionaries sent to Uganda to spread the church's gospel.
The show will be directed by Parker and Avenue Q director Jason Moore.
Parker and Stone said in a joint statement the project was "a dream come true".
"Growing up in Colorado, a lot of our friends were Mormons and we always thought their book would make a great musical," they added.
Co-writer Lopez said the musical would be, "in many senses a big traditional musical comedy with, as you might expect, untraditional subject matter".
"I can't wait to see how Broadway audiences are going to react when they experience it," he added.
Details about casting and the theatre will be announced at a later date.
Parker and Stone previously co-wrote the songs in 1999 musical film South Park: Bigger, Longer and Uncut.
The 200th episode of South Park - known for its politically incorrect humour - will be shown in the US this week.
The first episode was shown in the US in 1997.