Everybody Hurts music video
Everybody Hurts, recorded to help Haiti's earthquake victims, has sold more than 453,000 copies in its first week to go straight to number one.
The record has notched up the biggest first week sales of any charity track this century, the Official UK Charts Company (OCC) has confirmed.
The REM cover features a host of stars including Leona Lewis, Kylie Minogue, Robbie Williams and Take That.
The recording of the Helping Haiti song was organised by Simon Cowell.
Proceeds will be split between the Disasters Emergency Committee (DEC) and The Sun newspaper's Helping Haiti campaign.
The song moves ahead of The X Factor Finalist's version of Hero as the charity song selling the most copies in its first week of release since 2000.
Westlife's Uptown Girl, released in aid of Comic Relief, falls back to third place.
UK TOP FIVE SINGLES
1 Everybody Hurts - Helping Haiti
2 Fireflies - Owl City
3 If We Ever Meet Again - Timbaland ft Katy Perry
4 Empire State of Mind - Alicia Keys
5 Don't Stop Believin' - Glee cast
Source: Official Charts Company
The OCC's Martin Talbot said: "The public have clearly taken the plight of the Haitian people to heart - this record is huge."
HMV spokesman Gennaro Castaldo added: "It's already the biggest seller of the year so far, and is now likely to go on to be the number one single of 2010."
Elsewhere in the singles chart, the cast of Glee notched up another top 10 hit with their medley of Halo and Walking On Sunshine, in at nine.
Their cover of Don't Stop Believin' is in fifth place, while another mashup from the hit TV show becomes a new entry at 14.
In the album chart, Alicia Keys' The Element of Freedom remains at number one, with Andre Rieu's collection of Viennese waltz music still in second spot.
Sade's comeback album Soldier of Love enters the rundown at four, with Heligoland by Massive Attack new at six.
Albums from Michael Buble and the Black Eyed Peas enjoyed a resurgence, clambering back into the top 10.