Ferrera won a Golden Globe for the role in 2007
Award-winning TV comedy Ugly Betty has been axed in the US after four series, TV network ABC has announced.
The show, starring America Ferrera as a style-challenged woman working at a New York fashion magazine, was a critical success when it began in 2006.
But the show has struggled recently, with ratings in the US falling from an average 8.1m to 5.3m viewers between the third and fourth series.
ABC said the show will conclude its run in April.
"We've mutually come to the difficult decision to make this Ugly Betty's final season," executive producer Silvio Horta and ABC president Steve McPherson said in a joint statement.
"We are announcing now as we want to allow the show ample time to write a satisfying conclusion."
Based on Colombian telenovela Yo Soy Betty, La Fea - which translates as I Am Betty, the Ugly One - the show was adapted to a US setting by Oscar-nominated actress Salma Hayek, who also guest-starred in the series.
Ferrera became an overnight sensation when the show launched and went on to win a Golden Globe, for best TV comedy actress, and an Emmy, for best actress in a comedy series, in 2007.
The fourth series has yet to air in the UK.