By Tim Masters
Entertainment correspondent, BBC News
U2 will take a break from their North American tour to play Glastonbury
Bono has said that U2 are "delighted and humbled" to be headlining at next year's Glastonbury Festival over its 40th anniversary weekend.
The band will lead the line-up at the Somerset show on Friday 25 June.
"Everyone in the band is very excited about it," Bono told the BBC at the launch of an anti-Aids/HIV campaign.
It will be U2's first festival gig for more than 25 years and will see them make a flying visit to the UK in the middle of a North American tour.
Asked if he would use the festival to promote the campaign, Bono said: "I think it will just be about the music on that day, and that spirit that seems to take over everybody in that sacred ground."
He added: "We'll certainly be well-rehearsed, we'll be coming straight from the tour."
Bono was in central London on Monday to launch the "Lace Up. Save Lives" campaign - a partnership between Nike and the (RED) brand, which was co-founded by the U2 frontman.
He was joined at the launch, just ahead of World Aids Day, by Chelsea striker Didier Drogba and several other international football stars.
The campaign encourages people to buy red laces to help fund AIDS medication and education programmes in Africa.
Next year's Glastonbury takes place from 25-27 June - during the 2010 World Cup in South Africa.
No other headliners have yet been confirmed. David Bowie has denied that he will join U2 on the bill, but it is rumoured that stadium rockers Muse could appear.
Tickets for the event sold out shortly after they went on sale last month.