Sir Elton toured the US with Billy Joel earlier this year
Sir Elton John has postponed the final concert of his UK tour at Liverpool's Echo Arena on Wednesday - the fourth he has had to shelve because of flu.
He had previously scrapped gigs in Sheffield on Friday, Newcastle on Saturday and Tuesday's Wembley Arena leg after doctors advised him to rest.
Promoters are trying to reschedule the gigs for dates in December.
A spokesman for the singer-songwriter, 62, said he was "terribly disappointed" at not being able to perform.
Sir Elton and Billy Joel were forced to cancel US dates after Joel fell ill back in July.
Joel was told to rest after coming down with "flu-like symptoms" and "extreme fatigue".
Sir Elton and Joel had been touring together for two months under the banner Face 2 Face, selling out arenas across the US.