The 35-year-old joined the station in 1997, initially working in the 0400 slot.
But the self-styled "saviour of Radio 1" never hid his ambition of landing what he considered to be the top job in radio.
Since taking over the breakfast slot from Sara Cox, Moyles's time on air has been extended twice and he has boosted the show's audience from 5.5 million listeners a week to the current level of 7.3 million.
His zoo-style format has won him a loyal audience, and his core team - co-presenter "Comedy" Dave Vitty, producers Rachel Jones and Aled Jones and newsreader Dominic Byrne - have been with him since the show started.
Sports reporter Carrie Davis replaced Juliette Ferrington in October 2004.
But Moyles's career on the station has not been without controversy, and he has previously drawn fire for jokes about Auschwitz and gay singer Will Young.
In July, the DJ hit out at BBC red tape and the lengths that the corporation goes to not to cause upset.
Some critics have also questioned whether Moyles can keep in touch with the young listeners the Radio 1 aims to attract.
Tony Blackburn gave up the breakfast show up when 29, saying at the time he was married and "didn't fit the image any more".
Earlier this year BBC Radio 1 denied that it was preparing to replace Moyles.
"He has a hugely successful show with over seven million listeners," a spokesman said at the time.
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