Madonna played a total of 85 shows
Madonna's Sticky and Sweet world tour made $408m (£250m), making it the highest grossing tour ever for a solo artist, promoters Live Nation said.
The Material Girl played her last gig on Wednesday in Israel, after performing in 32 countries.
The 51-year-old has broken her own record, set by her Confessions tour, which was named the all-time top in 2006, after it made $194m (£118m).
The Rolling Stones' Bigger Bang tour is the highest grossing tour of all time.
The tour, which ran from 2005 to 2007, made $558m (£341m).
"She is absolutely one of the great performers of all time," said Arthur Fogel from Live Nation.
"That this tour will take its place as the second highest grossing tour in the history of our business says it all."
Madonna played 85 shows and attracted thousands.
The star even set an attendance record for the biggest crowds in history in Zurich, Switzerland, where she drew 72,000 fans.
And in Helsinki, Finland, Madonna sold more than 85,000 tickets, making it the biggest single show by an artist in history in Scandinavia.