Ready for the Weekend is Harris's second album
Michael Jackson's seven-week run at the top of the UK album chart has ended after a new entry from Calvin Harris went straight to number one.
Harris's Ready for the Weekend bumped Jackson's Essential Collection off the top spot.
There was also a new number one on the singles chart - Sexy Chick by David Guetta featuring Akon.
After its second spell at number one, the Black Eyed Peas' I Gotta Feeling slipped to number two.
Tinchy Stryder track Never Leave You entered the chart at number three.
UK SINGLES CHART
1. Sexy Chick - David Guetta featuring Akon
2. Black Eyed Peas - I Gotta Feeling
3. Tinchy Stryder - Never Leave You
4. Calvin Harris - Ready for the Weekend
5. Beyonce - Sweet Dreams
Source: The Official Charts Company
Harris's single, also called Ready for the Weekend, slipped to fourth spot.
Beyonce's Sweet Dreams and Remedy by Little Boots are at numbers five and six respectively.
Justin Timberlake protege Esmee Denters scored the highest new entry at seven with Outta Here. Mr Hudson and Kanye West's Supernova, Peter Andre's Behind Closed Doors and Ian Carey Project's Get Shaky rounded out the top 10.
Sales of Jackson's albums soared in the wake of his death in June. At one point, he had 11 albums in the top 200.
His posthumous reign at the top of the UK album charts beat his previous record - Thriller and Bad each spent five consecutive weeks at number one in the 1980s.