Cameron is the offspring of father Michael and his first wife Diandra Luker
Actor Michael Douglas says his family is "devastated" by the arrest of his son on drugs charges.
Cameron Douglas, 30, was arrested in Manhattan on 28 July and accused of selling methamphetamine.
"The family is devastated and very disappointed in Cameron's recent behaviour," said Michael and his former wife Diandra Luker in a statement.
"Any family who has dealt with substance abuse knows how devastating it can be," they added.
The statement was released to US magazine People.
Cameron Douglas faces a minimum 10-year jail sentence and a maximum of life if convicted of charges that he sold thousands of dollars worth of methamphetamine, also known as Crystal Meth.
He was arrested at a Manhattan hotel, and prosecutors allege he shipped large quantities of the drug from California to New York using the courier service Federal Express.
The 30-year-old, who had been confined to an apartment after his arrest, was transferred to jail this week after his girlfriend, Kelly Sott, allegedly tried to smuggle heroin to him.
According to court documents, a security guard overheard Douglas ask for a toothbrush on Monday, which his girlfriend delivered to him later that day.
A guard opened the battery compartment of the toothbrush and found "a brownish substance that appeared to be heroin," the federal complaint said. A field test showed it was about seven grams of the drug.
Sott was subsequently arrested.
Cameron Douglas appeared with his father Michael and grandfather Kirk in the film It Runs in the Family in 2003, a comedy showing three generations of a dysfunctional family.
His other films are Adam and Eve, The Perfect Beat and Loaded, with Jesse Metcalfe and Chace Crawford.
His most recent project, the crime drama Beautiful Outsiders with Corey Feldman, sees Douglas both in front of and behind the camera as associate producer. The film is still in production.