Alec Baldwin won best comedy actor last year for 30 Rock
Comedy 30 Rock, starring Alec Baldwin and Tina Fey, leads the nominations for this year's Emmy awards with 22.
In the best comedy category, which it has won for the past two years, it goes up against shows including The Office, Family Guy and Flight of the Conchords.
Briton Hugh Laurie is up for best drama actor for House while Kenneth Branagh is up for best actor in a mini-series or film for BBC One's Wallander.
The awards will take place on 20 September in Los Angeles.
Laurie, 50, has previously won two Golden Globes for playing Dr Gregory House.
Branagh, meanwhile, is up for his performances as the eponymous police chief in the TV adaptation of the Wallander novels, by Swedish author Henning Mankell.
The show's director Philip Martin is also nominated for an award.
Branagh is up against fellow Briton Sir Ian McKellen, 70, who is nominated for the film version of the Royal Shakespeare Company's King Lear - first shown in the UK on More4.
BBC period dramas Little Dorrit and The Tudors received 11 and five nods respectively.
Sir Tom Courtenay and Andy Serkis, who starred together in Charles Dickens adaption Little Dorrit, will compete in the best supporting actor in a mini-series or movie category.
Entourage, How I Met Your Mother and Weeds complete the line-up of best comedy series contenders.
Grey's Anatomy star Chandra Wilson and The Big Bang Theory's Jim Parsons, who announced the awards together, were both featured on the list.
"No. This is some sort of trick fest," said Parsons when his nomination for best actor in a comedy series was announced.
Wilson is up for best actress in a mini-series or movie, for Accidental Friendship, and supporting actress for Grey's Anatomy.
"I'm going to the party," she said.
TV movie Grey Gardens, starring Drew Barrymore, got the second most nominations with 17 awards.
Mad Men, which won the best drama prize last year, will compete against controversial polygamy series Big Love, Damages, Breaking Bad, Dexter, House and Lost in the same category this year.
The 1960s-set period drama is up for 15 other awards.
Glenn Close, who was named best actress in a drama for Damages last year, is up for the same award again.
She is up against Brothers and Sisters star Sally Field, Elisabeth Moss from Mad Men, Holly Hunter for Saving Grace, and Law and Order's Mariska Hargitay.
British actor Hugh Laurie, who stars in House, is up against nominees including Michael C Hall, for Dexter, and Mad Men's Jon Hamm in the best actor in a drama series category.
Hugh Laurie is up for best actor in a drama series
30 Rock is set behind the scenes on a fictional sketch show.
Its creator Tina Fey, who also writes and stars in the show, has again been nominated for best comedy actress.
The star - who scooped the award last year - will go up against actresses including Samantha Who? star Christina Applegate, Sarah Silverman for The Sarah Silverman Program, and Julia Louis-Dreyfus for The New Adventures of Old Christine.
Alec Baldwin - winner of last year's best comedy actor for 30 Rock - is up for the same award this year, competing against nominees including Parsons, Jemaine Clement for Flight of the Conchords, Steve Carell for The Office and Charlie Sheen for Two and a Half Men.
Weekly late-night sketch show Saturday Night Live features in 13 categories with sometime contributor Justin Timberlake nominated for best guest actor in a comedy series.