Richard and Judy first presented ITV's This Morning in 1988
Richard Madeley and Judy Finnigan's chat show on digital channel Watch is broadcast for the last time on 1 July.
The married couple have hinted it may be the last time they host a programme together.
After 21 years as a presenting duo, here are some of their more memorable television moments.
In May 1994, with Judy off work with flu, Richard was alarmed to read, on his way to the This Morning studios at the Albert Dock in Liverpool, about a spate of parcel bombs delivered to celebrities. He called his wife, warning her not to open any packages.
Judy promptly called police when she saw that a brown padded envelope had been pushed through their letterbox and bomb squad officers were sent to their home in Didsbury, Manchester.
The panic ended when it transpired the suspect package was in fact a silk tie sent as a gift to Richard by fashion designer Jeff Banks.
WEATHER MAP STREAKER
Agony aunt Denise Robertson was on the show from the start in 1988
A well-loved feature of the pair's This Morning show was a floating map of the British Isles in the middle of the Albert Dock where weatherman Fred Talbot forecast the nation's meteorological prospects, often jumping from region to region.
In 1995, a streaker swam across the water and jumped onto the map, causing the weatherman to wince and Richard and Judy to collapse with laughter.
Judy took a break from the show in 1998 to recover from a hysterectomy
In June 1998, with This Morning now relocated to studios in London, the show celebrated the work of The Naturist Foundation by featuring three naked guests.
But producers had their work cut out to protect the modesty of the naturist guests, making them wear aprons in a cookery slot and, at one point, covering a man's groin with the This Morning logo.
When Richard accused Diana Tebenham of covering herself up by folding her arms, she replied: "That's because your producers asked us to sit like this while on air."
In 1999, the show, with the help of resident doctor, Chris Steele, created television history by showing the first live TV testicular examination.
A brave volunteer was the focus of the item, while Richard sagely informed the nation that a man's left testicle often hangs lower than his right.
RICHARD'S ALI G MOMENT
Richard caused Judy visible embarrassment on an edition of This Morning in 2000 by arriving at work dressed as Ali G.
He was then interviewed by his wife, giving his answers in character as Sacha Baron Cohen's famous spoof character.
His appalling impression was later voted one of the worst television moments of all time.
JUDY'S WARDROBE MALFUNCTION
The couple have won a number of television awards
In the same year, Judy suffered a very public wardrobe malfunction as she accepted the award for most popular daytime programme at the National Television Awards.
She initially didn't notice her top had popped open and her bra was on display as she made her acceptance speech in front of 12 million viewers.
Richard took matters a step further as he held up the award the next morning and described it as "not the nicest globe on display last night".
Mark Jinks and Neil Morris were joined in partnership on the show
The broadcasting boundary-pushers broke another television taboo when they screened the first gay partnership celebration live on air on Valentine's Day in 2001.
Manchester couple Mark Jinks and Neil Morris were at the centre of the ceremony, with Mr Jinks' mother getting a makeover before proceedings - another mainstay of the couple's long-running magazine programme.
The pair bid an emotional farewell to This Morning in 2001
On their This Morning leaving show on 12 July 2001, singer George Michael called the show.
He thanked the couple for "easing me into the day for about the past 10 years".
"You will be sorely missed in this household," he added.
He praised agony aunt Denise Robertson as "a diamond" but said Richard "spouted rubbish".
In January 2007, Madeley revealed to the world that both he and his wife had tried Viagra. He explained that it was left over from a television feature about impotence and he didn't want it to go to waste.
"We had one each," he said. "It makes everything last much longer and return, you know, swiftly and hang around all day."
QUIZ SCANDAL APOLOGY
The couple's book club brand has been a big hit
On Monday February 19, 2007, the couple were forced to apologise to viewers of their Channel 4 show over their You Say, We Pay quiz.
They said they were "very sorry" about claims in the weekend papers that callers were told to phone a premium rate number even after contestants had been chosen to take part.
"Richard and I knew nothing about this until late on Friday afternoon - we were very shocked and also angry on your behalf," Judy said.