Ennis House was placed on a list on most endangered house in 2005
US architect Frank Lloyd Wright's Ennis mansion, used as a backdrop for films including Blade Runner, has been put on the market for $15m (£9.1m).
Guardians of the striking Los Angeles house, built from Mayan-inspired concrete blocks in 1924, are hoping to find a private buyer to preserve it.
The building was also used for Buffy The Vampire Slayer, Twin Peaks and the video to S Club 7's hit Have You Ever?
Wright, who died in 1959, was one of the world's most prolific architects.
South Park appearance
His grandson Eric has backed the decision of the Ennis House Foundation to put the estate on the market, saying his grandfather "designed homes to be occupied by people".
The organisation recently completed part of a restoration programme after the house was damaged by years of decay and heavy rains.
The house is made up of 27,000 concrete blocks
Its president James DeMeo said an individual would be better placed to save the house for future generations.
Actress Diane Keaton, who is one of the foundation's directors, is expected to take a public role in the sale of the house.
Ennis's other big screen appearances include the films Black Rain, The Karate Kid III and 1975's The Day of the Locust.
It was used in an episode of animated TV series South Park as the base for a Chinese gang.