The original artwork will feature in Squire's latest solo exhibition
The Stone Roses will never reform, the band's guitarist John Squire has said.
Asked on BBC Newsnight whether there was any chance of the group playing again, he replied: "None whatsoever."
Squire, now an artist, earlier used one of his own artworks to respond to press speculation that the Manchester band had agreed to a 21-date comeback tour.
A message superimposed onto a piece of art said: "I have no desire whatsoever to desecrate the grave of seminal Manchester pop group The Stone Roses."
The Stone Roses were one of the most revered bands of the late 1980s and '90s, with their debut album still regarded as one of the landmark releases of British guitar music.
But Squire has not spoken to singer Ian Brown since he left the group in 1996, he told Newsnight.
Asked whether never really meant never, he replied: "Yeah, I'd rather live my life than attempt to rehash it.
"It would be pointless. I find art far more challenging and rewarding."
John Squire: "I'd rather live my life than attempt to rehash it"
Speculation about a Stone Roses reunion has resurfaced ahead of the 20th anniversary of the release of their debut.
The album has recently been remastered by its original producer John Leckie and a deluxe anniversary edition will be issued in the UK in June.
"Even if Ian and I were still double dating as we did in our teens, then the prospect of a reunion wouldn't interest me at all," Squire said.
"There are usually rumours flying around but this one was particularly virulent, so I decided to post an image on my website to lay it to rest and hopefully it will work.
"There are fans but there is also a market there to exploit and I suspect this [reunion story] is being driven by people within the industry that have a vested interest."
The guitarist also designed the iconic Jackson Pollock inspired cover for the debut album, which came out in May 1989.
The Stone Roses were one of the most influential bands of the 1980s and '90s
The group's second album came out in 1994 and Squire left the group two years later, with the band finally dissolving several months later.
Squire went on to form The Seahorses and release two solo albums but switched his attention to art in 2004.
He will hold a major solo exhibition in Oldham from July to September, before taking it to Austria and Tokyo.
"I think music's a young man's game and I don't think us old fogeys should get in the way of that," Squire added.
"I've got a lot of great memories from those days but it was a long time ago. I think I have an urge to create and so long as I can satisfy that urge in one way or another, then I'm quite happy."
He also created the artwork for War Child Music's recent Heroes album cover, and his original painting will be auctioned for the charity on eBay from Monday.
Since the group split, Brown has forged a successful solo career and bassist Mani has become a member of Primal Scream.