Coldplay have scooped two prizes at the Q Awards ceremony in London, including best album for Viva La Vida or Death And All His Friends.
The band, fronted by Chris Martin, also won best act in the world today.
Welsh star Duffy won best breakthrough, while Keane picked up best track for comeback song Spiralling.
The music magazine also honoured veteran artists including Grace Jones, who was named Q Idol, and Glen Campbell, winner of the legend award.
Picking up the best album prize, Chris Martin warned the crowd he was going "to bore the pants off them", before launching into a rambling acceptance speech.
At one point, he declared Coldplay were "the greatest band in the world", before adding bashfully: "Well, not quite the biggest band. U2 are on holiday. Radiohead are on holiday."
When Martin returned to receive the best act in the world today award, he said: "I don't think we're the best act in the room, let alone the world."
Meat Loaf was presented with the classic song award for his epic Bat Out Of Hell.
The singer turned up at the ceremony sporting a cut eye and looking unwell, telling reporters he would have to visit a doctor, and that he was suffering from vertigo.
Q Award winners talk about their success
He had to be helped on and off the stage and he left the ceremony soon after picking up his award from comedian Al Murray, having been checked over by a paramedic.
The Cocteau Twins were honoured by the magazine with a prize for inspiration.
The band's Liz Fraser told the ceremony: "This is the first award we've ever won."
Pink Floyd's David Gilmour, meanwhile, was honoured with the outstanding contribution to music award and dedicated it to bandmate Richard Wright, who died last month.
He proposed a toast to the late keyboardist, asking everyone in the audience to stand and raise their glasses.
"There's all sorts of music that I will not be able to play again without him. That's a source of sadness for me," said Gilmour.
When accepting his award for Q Icon, Adam Ant said: "It's good to be standing here. It's very good to be standing, actually."
Kaiser Chiefs gave their best live act trophy to their tour manager, crediting with getting them on flights at 5am.
Q idol winner Grace Jones sported a costume with illuminated horns
Vampire Weekend's A Punk was judged best video by readers of Q, but the New York band lost out in the best new act category to The Last Shadow Puppets, the side project of Arctic Monkeys star Alex Turner.
The Ting Tings were shortlisted in three categories, but left the ceremony empty-handed.
Both nominees and winners were selected by readers of the monthly music magazine.
Accepting the best track award, Keane's Tom Chaplain said: "I just read Q's review of our record and ironically the only song they hated was Spiralling, so thanks readers for disagreeing with the editor."
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