Edwards left the show to spend more time with his family
Actor Anthony Edwards is to reprise his role as Dr Mark Greene in the final series of US medical drama ER.
His character, who died in 2002, will appear in flashback form with both past and current characters.
But broadcasters NBC have not revealed if other past stars - including George Clooney - will be in the final run.
Edwards was an original cast member, appearing in the show's pilot episode in 1994. His character eventually succumbed to a brain tumour.
NBC has said the star will appear in an episode called Heal Thyself, appearing in scenes with actress Angela Bassett, who is joining the cast of ER for the final season.
The instalment is due to be screened in the US on 13 November, while Edwards is scheduled to begin filming his scenes next week.
While there is no word on a possible return for Clooney, the Oscar-winner made a surprise cameo appearance in an episode in 2000 to mark the departure of long-running star Julianna Margulies.
He left the show in 1999 to pursue his film career on a full-time basis.
Another of the show's famous faces, Noah Wyle, is due to make a comeback in four episodes of the final series.
The show, set in the fictional Chicago County General Hospital, was the top-rated show on US TV for several years, but ratings have recently declined.
In 1996, the programme won an Emmy Award for outstanding drama series.