A mixture of "sunshine and showers" are expected throughout the weekend.
Lenny Kravitz, Maximo Park, the Charlatans, The Hoosiers and Alanis Morissette are also on the bill at the festival, which is now in its 13th year.
On Wednesday, headliners The Verve denied reports they were set to pull out of their V Festival slot.
The announcement followed claims that guitarist Nick McCabe is suffering from exhaustion after the band's recent appearance at the Summer Sonic festival in Japan.
Kanye West, the Foo Fighters, Mika and the Killers were among the acts who appeared in 2007.
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