Stephens and Suchet will star in the radio version of Dr No
Actor Toby Stephens, who played villain Gustav Graves in Die Another Day, will play James Bond in the first full radio adaptation of Dr No.
Poirot star David Suchet will play villain Dr No in the Radio 4 adaption, being broadcast on 24 May to mark 100 years since author Ian Fleming's birth.
The station will also air a documentary following Fleming's niece's attempts to find out more about her uncle.
The two programmes are of a season honouring the Bond creator.
In James Bond, The Last Englishman, Professor David Cannadine argues that the Bond novels have played a key role in shaping England's national self-image.
Radio 4 will also re-run Amis, Amis and Bond, featuring writer Martin Amis talking about his father's obsessive interest with Bond and Fleming's writing.
Published in 1958, Dr No was Fleming's sixth Bond novel, and four years later became the first to be made into a film.
It sees Bond sent to Jamaica to investigate the mysterious disappearance of two of his colleagues.
The Radio 4 adaptation's cast also includes Samuel West, John Standing, Martin Jarvis and Peter Capaldi.