Amy Winehouse will not perform at this year's Grammy Awards after her US visa application was rejected by the country's embassy in London.
Amy Winehouse plans to appeal against her cannabis fine
The singer was fined for cannabis possession in Norway last year.
A spokesman for the troubled star said she was "disappointed", but had "accepted the ruling and will be concentrating on her recovery".
Winehouse has been nominated for six Grammy Awards ahead of the ceremony in Los Angeles on Sunday.
They include the major prizes of record, album and song of the year.
She is now expected to perform via satellite during the ceremony instead.
AMY WINEHOUSE IN THE US
Nominated for six Grammy Awards
Sold 1.5 million copies of her album Back To Black
Album reached number six in Billboard charts
Cancelled North American tour last August
Also cancelled appearance at MTV Music Video Awards 2007
A statement from her management company did not say why her application was turned down.
The US Embassy in London and the State Department in Washington also declined to comment.
BBC entertainment reporter Colin Paterson said: "The blow to Amy Winehouse is that this was going to be one of the highlights of her whole career.
"She was going to be on the same bill as Aretha Franklin, Tina Turner, Jerry Lee Lewis, Little Richard, Herbie Hancock - all-time greats.
"The Grammys was the carrot her family and record company used as a way to persuade her to get into rehab. Now they're going to have to find another way to motivate her."
The star, whose hits include Back to Black and Rehab, entered a rehabilitation centre last month a few days after a video emerged that apparently showed her smoking a crack pipe.
Beyonce will duet with Tina Turner at this year's ceremony
And she is planning to appeal against the cannabis fine in a Norwegian court later this month.
Winehouse called off a series of concerts and appearances at the end of last year after reportedly being treated for drug addiction.
Back To Black was the biggest-selling album of 2007 in the UK after shifting more than 1.85 million copies.
The Grammys is the most prestigious award event in the music industry's calendar.
This year, Tina Turner and Beyonce will perform a duet and Andrea Bocelli, Josh Groban, Fergie and Alicia Keys are among the other performers.
Award presenters include Stevie Wonder, Prince, Tony Bennett, Nelly Furtado, Ringo Starr and Tom Hanks.