Madonna, Genesis, James Blunt and the Red Hot Chili Peppers will be among the headliners at the London show of the global series of Live Earth concerts.
Madonna has played at Wembley for gigs such as her Girlie Show tour
They will be joined at Wembley Stadium by groups including Foo Fighters, Duran Duran, Snow Patrol and Razorlight.
Seven Live Earth shows will take place around the world on 7 July as a way of highlighting climate change.
In the US, The Police, Kanye West and Bon Jovi will be among the artists at the Giants Stadium in New Jersey.
The Smashing Pumpkins, Alicia Keys, Kelly Clarkson, KT Tunstall, Fall Out Boy and Pink Floyd legend Roger Waters will also perform at the US leg.
Red Hot Chili Peppers (above)
More acts are still to be announced for both venues. There will also be concerts in Johannesburg, Rio de Janeiro, Shanghai, Sydney and Tokyo.
The diverse London line-up also includes rap group The Beastie Boys, singer-songwriters David Gray and Damien Rice and R&B pianist John Legend.
The Black Eyed Peas, Bloc Party, Corinne Bailey Rae, Keane and Paolo Nutini complete the Wembley bill so far.
Tickets for the UK show will be allocated by a ballot and fans must register their interest online for 72 hours from 1200 BST (1100 GMT) on Friday.
Tickets, priced £55, will be limited to two per person and can be bought from 18 April.
The Police (above)
Fans can buy tickets for the US show from 1000 EDT (1500 GMT) on 16 April.
The concerts aim to set a "green example" for other music events by using measures such as eco-friendly electricity, sustainable lighting and carbon-neutral travel.
Former US Vice-President Al Gore, who is one of those involved in organising the events, said he expected Live Earth to attract "an audience of billions".
"We hope Live Earth will launch a global campaign, giving a critical mass of people around the world the tools they need to help solve the climate crisis," he said.
All profits will go to organisations including the Alliance for Climate Protection, the Climate Group and Stop Climate Chaos.
The BBC has confirmed that it will be broadcasting the concerts on TV and radio in the UK.