Audioslave frontman Chris Cornell is leaving the rock supergroup, blaming "irresolvable personality conflicts as well as musical differences".
Chris Cornell found fame in 1990s grunge band Soundgarden
The singer, who also performed the latest James Bond theme tune, will release his second solo album in May.
Cornell formed Audioslave in 2001 with three former members of Rage Against the Machine, who will reform in April.
The star said: "I wish the other three members nothing but the best in all of their future endeavours."
Cornell, 42, found fame as singer and guitarist with Seattle grunge band Soundgarden, who split in 1997. He released his first solo album, Euphoria Morning, in 1999.
Cornell also wrote and sang You Know My Name - the theme to Casino Royale, starring Daniel Craig.
Meanwhile, Rage Against the Machine will reunite to perform at this year's Coachella Valley Arts and Music Festival, which runs from 27-29 April.
Rage Against the Machine and Audioslave guitarist Tom Morello has said the concert will be a one-off.
Morello is also releasing a debut solo album, One Man Revolution, on 24 April, under the name The Nightwatchman.