Cars has won the best film prize at the 34th Annie Awards, which honours the best in film and TV animation.
Cars follows Lightning McQueen, a vehicle voiced by Owen Wilson
The Disney and Pixar film, which features the voices of actors Owen Wilson and Paul Newman, took the best animated feature award.
British actor Sir Ian McKellen was honoured at the California ceremony for his portrayal of a toad in Aardman movie Flushed Away.
It also won prizes for writing, design, effects and character animation.
Cars is about a cocky race car which learns the wisdom of slowing down.
Director John Lasseter, praised his fellow film-makers, who released more than a dozen animated movies last year.
"What a year we've had in animation," he said.
The award for best directing went to Tim Johnson and Karey Kirkpatrick for Over the Hedge, which is based on a US comic strip about animals whose woodlands are taken over by surburbia.
The Annie Awards provide an important guide to which animated films which are likely to do well at the Oscars on 25 February.
Every single Academy Award for best animated feature has gone to the movie which wins the top prize at the Annie Awards.
This year, Cars will compete against Monster House and Happy Feet.