Doctor Who, TV chef Jamie Oliver and actor Rowan Atkinson are to appear with Dennis The Menace in the Beano.
A special edition of the children's comic has been created to raise money for the Comic Relief charity.
It sees troublesome pupils The Bash Street Kids forced to study by the Daleks and Jamie Oliver cooking up dinner in the school canteen.
"Dennis and the rest have promised to be gentle with them," said Beano editor Euan Kerr of the celebrity guests.
The special edition is also the first issue of a new monthly publication, BeanoMAX, which will run in tandem with the regular weekly Beano comic.
It is aimed at readers aged nine to 13, an older audience than the Beano traditionally enjoys.
Other stars lined up for appearances include pop band McFly, broadcaster Jonathan Ross and footballers Frank Lampard and Steven Gerrard.
The Beano, published by Dundee-based DC Thompson, celebrates its 70th anniversary next year.
It has appeared regularly since its launch in 1938, but during World War II it appeared only on alternate weeks due to a newsprint shortage.
The original cover star was Big Eggo the Ostrich, drawn by Reg Carter.
He stayed on the front page until 24 January 1948, when he was ousted by newcomer Biffo The Bear.
Dennis The Menace, "The World's Wildest Boy", made his debut on 17 March 1951, but did not wear his familiar red and black striped jumper until May of the same year.
He soon became a firm favourite, accompanied by his scruffy black dog Gnasher.
This year's Comic Relief Day takes place on 16 March. The BeanoMAX comic goes on sale on 15 February.