Fantasy comedy Night at the Museum has knocked animated penguin movie Happy Feet from the UK box office top spot.
Stiller's movie has also topped the box office in the US
The film, which stars Ben Stiller as a security guard facing exhibits which come to life, took almost £4m over the first weekend after Christmas.
Happy Feet was well beaten with takings of £1.8m, while Casino Royale hung onto third place with £1.4m in sales.
Body-swap comedy It's a Boy/Girl Thing is a new entry in fourth place after making £967,903.
Transatlantic romance The Holiday, starring Cameron Diaz, Kate Winslet and Jude Law falls to fifth place, ahead of another animated animal movie, Flushed Away.
Time travel thriller Deja Vu is at number seven with dragon fantasy Eragon, literary adaptation Perfume and Clint Eastwood's World War II epic Flags of Our Fathers rounding out the top ten.
The top money-making movie is Casino Royale with a total UK gross of £49.6m seven weeks after its release.