Ferrell is reunited with Anchorman director Adam McKay
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The Will Ferrell motor racing comedy Talladega Nights: The Ballad of Ricky Bobby has sped to the top of the box office chart in north America.
The movie took $47m (£25m) in its opening weekend, according to early studio estimates.
This would make it the second-biggest opening by a non-sequel comedy, behind Bruce Almighty's $68m (£36m) in 2003.
The animated Barnyard: The Original Party Animals opened second, taking an estimated $16m (£8.4m).
The year's biggest movie, Pirates of the Caribbean: Dead Man's Chest, was third in the chart with estimated receipts of $11m (£5.8m).
'On a roll'
Last weekend's number one, Miami Vice, fell to fourth place in its second weekend. It took an estimated $9.7m (£5.1m).
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NORTH AMERICAN BOX OFFICE
1. Talladega Nights: The Ballad of Ricky Bobby
2. Barnyard: The Original Party Animals
3. Pirates of the Caribbean: Dead Man's Chest
4. Miami Vice
5. The Descent
6. John Tucker Must Die
7. Monster House
8. Ant Bully
9. The Night Listener
10. You, Me and Dupree
Source: Exhibitor Relations
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British horror film The Descent, made by Dog Soldiers director Neil Marshall, opened in fifth place with $8.8m (£4.6m).
Box office tracker Exhibitor Relations said takings for the top 12 films were up 17% on the same week last year.
"Hollywood's on a roll. Last year at this time it was all gloom and doom," said president Paul Dergarabedian.
"Eighteen of the past 20 weekends have been up over last year. This is a terrific summer."