Pirates of the Caribbean: Dead Man's Chest has set an opening weekend record at the North American box office.
Producer Jerry Bruckheimer said the takings exceeded his expectations
The film took an estimated $132m (£71m) in its first three days, beating the previous best debut of $115m (£62m), set by Spider-Man in 2002.
It generated almost three times the opening weekend total of the original Pirates film - also with Johnny Depp and Keira Knightley - two years ago.
Last weekend's top release, Superman Returns, fell to number two.
The superhero's comeback took $21.9m (£11.8m), down 58% from last week.
NORTH AMERICAN TOP 10
1. Pirates of the Caribbean: Dead Man's Chest
2. Superman Returns
3. The Devil Wears Prada
6. Nacho Libre
7. The Lake House
8. The Fast and the Furious: Tokyo Drift
9. Waist Deep
10. The Break-Up
Source: Exhibitor Relations
Disney - which released Pirates of the Caribbean: Dead Man's Chest - said it had received reports of continuous sell-outs for the film, with requests to add screens at multiplexes.
The sequel also set records on Friday for the best single-day total with $55.5m (£30m) and on Saturday as the fastest movie to reach $100m (£54m).
"When people in the industry predicted these high numbers, I thought they were just trying to be mean," producer Jerry Bruckheimer told the AP news agency.
"No matter how good we did, if we did $100m, we'd be failures. I didn't think we'd get near these numbers."
The first film, The Curse of the Black Pearl, made $654m (£353m) and earned Depp an Oscar nomination. A third instalment is currently in production.
Fashion satire The Devil Wears Prada, romantic comedy Click and Disney-Pixar animation Cars made up the rest of the top five.