Andrew Lloyd Webber's musical The Woman in White is closing on Broadway after only three months.
Maria Friedman previously appeared in the West End production
The curtain will close on 19 February, a week before the West End version shuts down following a 19-month stint.
Audiences in New York have not been as good as expected - producers said problems had been caused by illnesses among the cast.
The London show, adapted from the Wilkie Collins novel, will begin a year-long national UK tour in January.
"There have been performances when two or more leads have been absent due to illness," said Lloyd Webber of the Broadway production.
"I'm not sure even The Phantom of the Opera could have survived the illnesses which have beset this wonderful company," he added.
Leading lady Maria Friedman, who plays heroine Marian Halcombe, was diagnosed with breast cancer two weeks before opening night.
She went ahead with her first night performance and won rave reviews.
Her co-star Michael Ball, who plays Count Fosco, then contracted a serious viral infection.
"As a result of these and other health issues among the company, audiences got to see the entire original cast perform just 31 of the 108 performances played to date since the show's first preview," said producer Boy Boyett.
He said he was interested in the possibility of a US tour and would discuss plans with Lloyd Webber's Really Useful Group and London producer, Sonia Friedman.
Friedman was due to take six weeks off from 12 February but will now continue in the show until it finishes.