Comedy drama Desperate Housewives is expected to pick up several Emmy nominations on Thursday.
The first series of Desperate Housewives has ended in the UK
The show, which has proved a hit on both sides of the Atlantic, is tipped to give US network ABC its best showing at the television awards for years.
The programme has been entered as a comedy, so is expected to benefit from the end of Friends and Sex And The City, which ended in the last year.
Drama The West Wing will be looking for its fifth successful year in a row.
A nomination for best series for Desperate Housewives would give ABC a crack at its first comedy award since Home Improvement in 1994.
The network last scooped an Emmy for best comedy in 1988 with The Wonder Years.
Desperate Housewives creator Marc Cherry said the series is more of a drama, but added "we're a weird fit wherever you put us".
As for pundits tipping the show to get up to 20 nominations, he says it is unpredictable.
"Some great shows like Moonlighting were always bridesmaids, and we can't take anything for granted.
The Sopranos will not be eligible for this year's awards
"For a first-year show like us to get even a few nominations, I'll be ecstatic. We'll be keeping our expectations modest," said Mr Cherry.
Other comedies that could be competing head-to-head with Desperate Housewives is last year's winner Arrested Development, and the final series of Everybody Loves Raymond.
It seems likely that pay-tv network HBO will come away with far fewer nominations than last year's 124.
But the network is now without Angels, which gained 24 nods, Sex And The City and The Sopranos, which did not air during the past year.
The broadcaster, which had almost double the nominations of its nearest rival NBC last year, could be without a representative in the comedy serial category for the first time in 13 years.
The Emmy Awards ceremony will take place in Los Angeles on 18 September.