Christopher Eccleston has quit the role of Doctor Who after filming one series, leaving the show's title role vacant.
David Tennant is among the actors tipped to play the next Doctor
As the BBC confirmed it would film another series of the popular show, a number of actors have been suggested to play television's 10th Doctor.
Here are some of the actors tipped by TV pundits, fans and bookmakers to take the role.
David Tennant, 33, recently starred in Casanova - a BBC drama based on the legendary lothario written by Russell T Davies, the lead writer in the latest series of Doctor Who.
The actor from Bathgate, West Lothian, also took major roles in BBC shows Blackpool and He Knew He Was Right, appeared in the Stephen Fry movie Bright Young Things and on stage in the Royal Shakespeare Company's Romeo and Juliet.
He plays Barty Crouch Jr in Harry Potter and the Goblet of Fire, currently in production.
A long-time fan of Doctor Who, Tennant voiced a role in internet episode Scream of the Shalka in 2003 and told the Guardian newspaper that his earliest memory was of seeing Doctor Who actor Jon Pertwee regenerate into Tom Baker.
Bill Nighy, 55, was previously tipped for the Time Lord role taken by Christopher Eccleston.
Nighy is best known for his comedy roles in films like Love Actually
His extensive television and movie credits include roles in 2003's Love Actually, Shaun of the Dead, Enduring Love and voice work in the recent film version of The Magic Roundabout
Born in Caterham, Surrey, his stage work includes National Theatre roles in Tom Stoppard's Arcadia in 1993, David Hare's Skylight and Blue/Orange.
Nighy's next high-profile role is as Slartibartfast in the film adaptation of The Hitchhiker's Guide to the Galaxy.
RICHARD E GRANT
Richard E Grant, 47, played the role of Doctor Who in the 2003 internet episode Scream of the Shalka.
Grant took the role of the Doctor in an internet adventure in 2003
Best known for playing alcoholic actor Withnail in 1987 film Withnail and I, Grant's big screen credits include Gosford Park, Hudson Hawk and a role alongside David Tennant in 2003's Bright Young Things.
Grant was also one of numerous actors to play the part in the spoof Doctor Who adventure, The Curse of Fatal Death, in aid of Comic Relief in 1999.
He appears in the John Malkovich film Colour Me Kubrick, currently in post-production, and is voicing a part in Tim Burton's next movie Corpse Bride.
David Thewlis, 42, is known for performances as intense as those of outgoing Doctor, Christopher Eccleston.
Thewlis starred in the acclaimed Singing Detective TV series
His 20-year TV and movie career began with television series Valentine Park, taking in acclaimed roles in The Singing Detective, Prime Suspect and Mike Leigh's Naked along the way.
Thewlis, from Blackpool, also wrote and directed 1995's short film Hello, Hello, Hello and 2003's movie Cheeky, in which he starred as a widower.
He subsequently played Professor Lupin in 2004 family film Harry Potter and the Prisoner of Azkaban.
Davies previously worked with writer Russell T Davies in Bob & Rose
Alan Davies, 39, has also previously worked with lead Doctor Who writer Russell T Davies, starring in 2001 television series Bob & Rose.
He moved from stand-up comedy to play Jonathan Creek in the long-running BBC TV series of the same name in 1997.
Other TV appearances include One For the Road and A Many Splintered Thing, and he is a team captain on BBC quiz show QI.
Born in Essex, Davies studied at the University of Kent at Canterbury before embarking on a comedy career.