Actress Gwyneth Paltrow will take the lead role in a low-budget romantic comedy directed by her brother, Jake.
Gwyneth is Jake's elder sister
The Oscar-winner has been cast alongside The Office actor Martin Freeman in The Good Night, reports in Hollywood newspaper Variety said.
Paltrow, 33, who starred in The Talented Mr Ripley and The Royal Tenenbaums, won best actress for her role in Shakespeare in Love.
Production on the £8.6m film starts in London and New York in November.
Freeman, who played hapless Tim in Ricky Gervais' comedy The Office, starred as Arthur Dent in The Hitchhiker's Guide to the Galaxy.
British actor Simon Pegg - Shaun, in Shaun of the Dead - has also been signed up for the film.
It will be shot in part at London's Ealing studios.
Jake Paltrow, 30, has directed US TV series The Jury and The Others.