The Comeback, starring Friends actress Lisa Kudrow, has been cancelled after one season by US cable network HBO.
LeBlanc (l) and Kudrow have both starred in sitcoms since Friends
The show, about a sitcom actress trying to revive her career, was described as "uniquely original" by a HBO publicist.
"However, given our future commitments, we felt we would not be able to give the show the support it needed."
Kudrow executive produced the show and wrote two of the 13 episodes. Fewer than a million viewers saw the season finale on 4 September.
The show, based on a character the actress invented during her time with Los Angeles improvised comedy troupe the Groundlings, used the same "mockumentary" format as The Office and HBO's Curb Your Enthusiasm.
"The Comeback is well versed in the transitory nature of stardom and inner workings of Hollywood," wrote Variety's critic when the series began in June.
"But those are hardly breakthrough observations, and the show's satirical jumping-off point feels pretty well saturated."
Kudrow is not the only former Friends star to face flagging ratings.
Matt LeBlanc's sitcom Joey has also fared poorly with audiences - though this has not stopped NBC commissioning another series, beginning on 29 September.