Star Trek: Enterprise, the latest TV incarnation of the sci-fi saga, is being axed by broadcaster UPN.
Quantum Leap actor Scott Bakula (front) stars in Star Trek: Enterprise
Its 98th and final episode will air in the US on 13 May, after a four-season run which struggled in the ratings.
Presented as a prequel to the original Star Trek television series, Enterprise made its debut in September 2001 starring Scott Bakula.
It followed earlier Star Trek spin-off series The Next Generation, Deep Space Nine and Voyager.
Set 100 years before Captain James T Kirk and his crew set off on their first mission, Enterprise made its UK debut on Sky One in 2002.
On its broadcast BBC correspondent Peter Bowes said: "Some fans may be disappointed by the emphasis on fast action rather than intellectual depth."
The series also received a mixed response from US critics and Star Trek fans.
With the original TV series first broadcast in 1966 - reaching the UK three years later - Star Trek also spawned 10 movie spin-offs, the most recent being Nemesis in 2002.