Music stars including Sir Elton John and Phil Collins are recording a single in London on Thursday to raise money for the tsunami relief fund.
Sharon and Ozzy Osbourne wanted to get involved with fundraising
The record, a cover version of Eric Clapton's 1991 hit Tears In Heaven, will also feature Rod Stewart, Gwen Stefani and Aerosmith's Steve Tyler.
The recording was organised by Sharon Osbourne, with vocals from rock star husband Ozzy and daughter Kelly.
A release date for the charity track has yet to be confirmed.
Sharon Osbourne said she felt personally affected by the tragedy because her family were due to visit Thailand three days after it struck.
"My heart goes out to every person affected by this tragedy and that is why I am putting this together in the hope of raising more funds to help these people rebuild their lives, especially the children," she said.
"Everyone has come together for this project and offered their time and full commitment without question."
The track will be partly recorded at Whitfield Studios in London, with other artists adding their vocals at a studio in Los Angeles next week.
Others who have pledge their time include Pink, tenor Andrea Bocelli and actor Robert Downey.
The music will be provided by Velvet Revolver, who include Guns 'n' Roses guitarist Slash and ex-Stone Temple Pilots singer Scott Weiland.
All proceeds from the single will go to Save The Children.
Tears in Heaven was originally written by Eric Clapton as a tribute to his four-year-old son Conor who died in 1991 when he fell from a window in New York.
Clapton will also be appearing alongside Keane and Manic Street Preachers at a tsunami benefit concert at the Millennium Stadium in Cardiff on Saturday.
Sir Cliff Richard, Russell Watson and Robin and Barry Gibb have joined together to another charity record called Grief Never Grows Old.