O'Connor was ordained as a priest in 1999
Singer Sinead O'Connor will retire from the music industry because she says fame has left her with "nothing left to give".
A message from the star, who has been making music for 20 years, said she would "pursue a different career" - but did not say what.
"I would request that as of July, since I seek no longer to be a 'famous' person, and instead I wish to live a 'normal' life, could people please afford me my privacy," she said on her website.
It comes 12 years after she first said she would quit music and four years after she became a "priest".
Her latest album was released in October and she recently appeared on the new Massive Attack album.
I am glad that ye are helped by my songs - so help me too, by giving me what is best for me, a private life
She said: "The last recordings I will make will be (believe it or not) a track for Dolly Parton's upcoming tribute album and a track for Sharon Shannon's forthcoming album."
They will be recorded in May and a DVD called Goodnight, Thankyou, You've Been a Lovely Audience, will come out in July.
"I wish to thank everyone who has been a fan and or supporter of mine over the last 22 years in the music business."
O'Connor said she did not want her name "exploited" by the press after July.
"I also mean that (with love) I want to be like any other person in the street and not have people say 'there is Sinead O'Connor'.
"I am a very shy person, believe it or not. So I ask with love, that I be left in peace and privacy by people who love my records too.
"And I hope it doesn't sound rude. It ain't meant rude. I am glad that ye are helped by my songs. So help me too, by giving me what is best for me, a private life."
She also told fans that the best way to show their love for a celebrity was to ignore them if they saw them.
"Leave them alone and don't stare at them! Or bang on restaurant windows when they in there. Or make them get their picture taken, or write their names on bits of paper. That's pieces of them," she said.
"And one day they wake up with nothing left of themselves to give."
O'Connor, 36, became an international star with her worldwide number one Nothing Compares 2 U.
But she also became known for her politics, infamously ripping up a photo of Pope John Paul II on US television.
When she refused to perform in the US if The Star Spangled Banner was played before her appearance, Frank Sinatra threatened to "kick her ass".
In 1992, she said she planned to retire to study opera and help children in her native Dublin.
She was ordained as a priest in 1999, in the Latin Tridentine Church, a splinter group of the Roman Catholic Church, and said she wanted to be known as Mother Bernadette.