Jobs are being lost in the service, business and manufacturing sectors
The United States government says it does not see an immediate need for new measures to stimulate the US economy despite a sharp rise in unemployment.
The latest figures show a rate of 6.1% - the highest since December 2003.
A White House spokeswoman said that while the figures were disappointing, the existing economic stimulus plan was having the impact intended.
A call for more action had been made by the Democratic Party presidential candidate, Barack Obama.
A higher-than-expected 84,000 jobs were lost last month, which together with the unemployment rate has added to concern about the US economy and its ability to stave off a recession.
In a further blow, the Labor Department revised upwards job loss figures for each of the past two months.
The Federal Reserve said earlier that economic activity remained "weak".
A separate report by the Mortgage Bankers Association said that almost one in 10 US mortgage holders were behind with their mortgage payments or was in foreclosure procedures.
The 9.2% default rate between April and June was up from 8.8% in the previous quarter, and nearly double the rate one year ago.
The number of jobs lost last month was significantly higher than the 75,000 forecast by economists.
All sectors of the economy were affected with manufacturing worst hit, shedding 61,000 jobs.
The labour market has worsened noticeably in recent months, reflected by the fact that it is now apparent that more jobs were lost in June and July than was previously thought.
Revised figures show that in June, 100,000 jobs were lost while in July 60,000 jobs disappeared. This was up from the 51,000 figure initially forecast for both months.
"It seems unemployment in the US really is accelerating," said the BBC's North America business correspondent, Greg Wood.
"There do not seem to be many sectors of the US economy which are hiring."
In the first eight months of 2008, 605,000 jobs have been lost.
Employers have now reduced their payrolls for eight straight months, with the dramatic downturn in the housing market and the credit crunch hurting all sectors of the economy.
"This is more convincing evidence that the economy is still in trouble," said Gary Thayer, senior economist at Wachovia Securities.
"The economy is clearly deteriorating."
Both candidates in November's Presidential election are under pressure to come up with concrete proposals to help the growing number of people out of work and families battling against rising living costs.
Although the US economy grew a robust 3.3% in the second quarter, businesses are struggling to cope with the high cost of raw materials and energy, fragile consumer confidence and weaker export markets.
The Federal Reserve, which meets to decide on interest rates next week, has warned that the US is facing the twin threats of weak growth and rising inflation.
The bleak employment picture means the Fed is unlikely to raise rates in the foreseeable future while further cuts seem equally unlikely against a background of rising inflation.
"The jobs number is weak again but we think this probably is not the time to panic," said Steve Goldman, strategist at Weeden & Co.
In an earlier version of this story we erroneously reported that more than 9% of all US homeowners were behind on their payments or facing repossession. This numbers applies to mortgage holders only.