The Doha development round of trade talks initially started in 2001 with the aim of remedying inequality so that the developing world could benefit more from freer trade.
However, the talks have repeatedly collapsed as developed countries failed to agree with developing nations on terms of access to each others' markets.
The US and the European Union want greater access to provide services to fast-growing emerging countries, including China and India.
Meanwhile, developing countries want greater access for their agricultural products in Europe and the US.
Analysts have said that the collapse of the Doha talks could symbolise an end to multilateral trade agreements.
America's top trade negotiator Susan Schwab on the talks
Instead, nations may pursue dual agreements with partner nations, preferring to focus on their own requirements rather than a more common negotiating goal.
The talks in Geneva were complicated by recent increases in the price of food and fuel.
Higher prices have prompted protests in both developed and developing nations, making it harder for negotiators to reach a compromise on opening up their markets to greater competition, analysts said.
Mr Mandelson, the EU trade commissioner, blamed the collapse on a "collective failure" but warned that the "consequences would not be equal", predicting that it would be countries that most needed help that would be hit hardest.
"They [the consequences] will fall disproportionately on those who are most vulnerable in the global economy, those who needed the chances, the opportunities most from a successful trade round." he said.
Trade officials had struck an optimistic tone on Friday, but this evaporated over the weekend amid acrimonious exchanges with the US accusing India and China of blocking progress.
The US said they were being overly protective towards their own farmers and are failing to do enough to open their markets, with US trade representative Susan Schwab calling the stance "blatant protectionism".
"In the face of the global food price crisis, it is ironic that the debate came down to how much and how fast could nations raise their barriers to imports of food," she said.
But India's trade minister, Kamal Nath, who had been criticised by a number of countries for his intransigence said the US demands were unreasonable.
"It's unfortunate in a development round we couldn't run the last mile because of an issue concerning livelihood security," Mr Nath said.
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