Glaxo has faced stiff competition from cheaper generic drugs
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GlaxoSmithKline, the world's second largest drug maker, is to cut 350 research staff as part of a plan to bolster productivity and cut costs.
The company did not say where it planned to make the cuts, which represent 2% of its 17,000 research and development (R&D) staff.
In October, Glaxo said it would cut jobs and possibly close some sites as part of a £700m cost-saving programme.
Glaxo faces falling profits due to competition from generic drug brands.
It is also experiencing an ever-dwindling pipeline of prospective future drugs, and various setbacks in releasing new products.
In a statement, the company said it was reshaping its R&D operations to "take advantage of new scientific opportunities and improve [its] productivity".
"Regrettably some job reductions are necessary and we will do everything we can to support these employees who are affected," the statement said.
The cost-saving programme announced in October is expected to amount to a pre-tax saving of up to £700m ($1.4bn) by 2010.
In February it confirmed it would cut 330 of the 537 jobs at its Cumbria factory.
Glaxo is the world's second largest drug maker after US drugs giant Pfizer.
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