A hotel spokeswoman said it would remain closed indefinitely, and 1,500 of its guests were evacuated to a high school.
Hickman county, to the east of Nashville, requested large quantities of water after their waste water and water treatment plants broke down.
Nashville Mayor Karl Dean inspected the damage from the air and said it was worse than he had expected.
"This situation is going to require a very large recovery process. The safety of some of our infrastructure is questionable," he told the Tennessean newspaper.
Kentucky Governor Steve Beshear has requested federal assistance to deal with the storm damage.
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