The blizzards have come as the region is still dealing with days of heavy snow.
Washington DC's winter snowfall total up to Wednesday morning of 54.9in (139cm) recorded at Reagan National Airport, had made the season the snowiest on record since 1899, the NWS said.
The Federal Aviation Authority said Dulles Airport near Washington DC would shut down for 24 hours due to the adverse conditions.
Schools closed in New York for only the third time in six years, and the United Nations said it had closed its headquarters in the city.
The storm arrived from the west, where as much as 17in of snow fell in the state of Iowa.
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As the storm closed in on the north-eastern US late on Tuesday, people raced to clear existing snow and stockpile food.
Thousands remained without power from the last storm a few days ago in parts of Pennsylvania, Maryland and other areas.
Philadelphia was expecting up to 19in of snow and Baltimore as much as 20in, according to the National Weather Service.
Baltimore was in the midst of its snowiest winter since records began, with Philadelphia forecast to also break its previous seasonal high of 65.5in.
In Washington, federal agencies are shut and the House of Representatives has called off all votes for this week.
The Senate is due to resume work on Thursday as the storm moves offshore.
The government closure is estimated to be costing $100m (£64m) a day in lost productivity and other costs.
Many of the region's schools are closed, with some cancelling classes for the rest of the week.
Transport has been widely disrupted, with airports in Washington shutting early on Tuesday. Airlines cancelled hundreds of flights, but some relaxed ticket policies to allow passengers to change their plans without penalty.
Washington's bus system has ground to a halt and its subway was partly suspended. Thousands of houses have remained without power in the Washington area.
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