US Republican John McCain moved closer to his party's presidential nomination after Super Tuesday's polls, while the Democratic race stayed finely balanced.
Mr McCain won the big states of California and New York, although Mike Huckabee did better than expected.
For the Democrats, Hillary Clinton won in New York and California, but Barack Obama won in 13 states. Both hailed a "great night" and a "big victory".
It was the biggest day in the race to pick candidates in November's election.
But the campaigns are already looking ahead to contests on Saturday in Louisiana, Nebraska and Washington state and primaries on 12 February in Maryland, Virginia and Washington DC.
Race not yet run
Mr McCain's gains seriously wounded his main rival, Mitt Romney, the BBC's James Coomarasamy in Washington says.
Democrats
Hillary Clinton 17 states, 1,592 delegates
Arizona, Arkansas, California, Florida, Massachusetts, Michigan, Nevada, New Hampshire, New Jersey, New Mexico, New York, Ohio, Oklahoma, Pennsylvania, Rhode Island, Tennessee, Texas
Barack Obama 24 states, 1,723 delegates
Alabama, Alaska, Colorado, Connecticut, Delaware, Georgia, Hawaii, Idaho, Illinois, Iowa, Kansas, Louisiana, Maine, Maryland, Minnesota, Missouri, Nebraska, North Dakota, South Carolina, Utah, Vermont, Virginia, Washington state, Wisconsin
2,025 delegates needed for nomination. Source AP (includes all kinds of delegates) Q&A: US election delegates
Arizona, California, Connecticut, Delaware, Florida, Illinois, Maryland, Missouri, New Hampshire, New Jersey, New York, Ohio, Oklahoma, Pennsylvania, Rhode Island, South Carolina, Texas, Vermont, Virginia, Washington state, Wisconsin
Mitt Romney 11 states, 251 delegates
Campaign suspended
Alaska, Colorado, Maine, Massachusetts, Michigan, Minnesota, Montana, Nevada, North Dakota, Wyoming, Utah
1,191 delegates needed for nomination. Source: AP (includes all kinds of delegates)
Mr McCain also won in Illinois, Oklahoma, New Jersey, Missouri, Connecticut, Delaware, and his home state of Arizona.
Speaking in Phoenix on Wednesday, Mr McCain said: "The majority of Republicans across the board have stated their view so I hope that we can now join together for the good of the party and the good of the conservative cause."
The Democratic race was as tight as forecast, although Mrs Clinton secured the two biggest prizes.
In New York, her home state, she captured about 57% of votes to Mr Obama's 40%.
In California, with most precincts counted, Mrs Clinton had won 52% of Democratic votes and Mr Obama about 42%.
Mrs Clinton also took Arizona, Massachusetts and New Jersey, as well as the southern, rural states of Oklahoma, Tennessee and Arkansas.
However Mr Obama won a greater number of states, namely Alabama, Alaska, Colorado, Connecticut, Delaware, Georgia, Idaho, Kansas, Minnesota, Missouri, North Dakota, Utah and his home state of Illinois.
I think we must get used to the idea that we are the Republican Party front-runner
The Democratic caucuses in New Mexico remained unsettled. Mrs Clinton had a 117-vote lead when the party shut down its counting operation. Counting was resuming on Wednesday morning.
Speaking in Chicago on Wednesday, Mr Obama said he had triumphed over Mrs Clinton by winning "more states and more delegates" on Super Tuesday.
"We had an extraordinary night. It was a big victory for our campaign," he said.
"I have great confidence this campaign is gaining momentum every day," Mr Obama added.
In terms of delegates captured, Mrs Clinton was only marginally ahead - under the Democrats' system of proportional distribution.
Both are still well short of the 2,025 needed to secure the party's nomination.
Mrs Clinton also hailed "a great night", and vowed to press ahead.
"We're going to compete everywhere and I'm very excited about competing. It's going to be a mad dash to Tuesday," she told reporters.
"We are at full speed ahead."
'All the way'
Overall, voters were choosing 42% of delegates on Super Tuesday.
In each state's primary or caucus, successful candidates are awarded delegates who formally choose the party's nominee at the national convention in six months' time.
In Arizona, Mr McCain's told supporters: "We must get used to the idea that we are the Republican Party front-runner for the presidency of the United States."
However it was Mr Huckabee who took the first state to announce a result, West Virginia.
WHAT IS SUPER TUESDAY?
24 states holding simultaneous contests to help decide the Democratic and Republican presidential nominations
About 40% of each party's delegates - who will choose the candidate - are up for grabs
Key states electing large numbers of delegates include California, New York and Illinois
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