Police representatives from 21 forces in Latin America and the Caribbean are meeting in Colombia to define the terms of a new regional police force.
Member forces will exchange information on trafficking
They hope the force, which will be known as Ameripol, will help strengthen regional co-ordination in fighting drugs trafficking and organised crime.
Colombia's Defence Minister Juan Manuel Santos said the force would have its headquarters in Bogota.
It would also aim to work closely with regional forces like Europol, he added.
The head of Colombia's national police, Oscar Naranjo, said members of Ameripol would exchange information "to assure all Americans that each country is free from threats".