Mr Khadr was captured in eastern Afghanistan when he was 15
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The US military has formally charged the only Canadian detainee at Guantanamo Bay with murder.
Omar Khadr, now 20, was 15 when he was captured in eastern Afghanistan in 2002 and sent to the prison.
He has also been charged with attempted murder, conspiracy, providing support to terrorism and spying.
Mr Khadr will be the second prisoner to face terror charges under new military tribunal process, following the trial of Australian detainee David Hicks.
He is expected to face a hearing within the next 30 days and a military trial at Guantanamo Bay within the next four months.
Born in Toronto, Mr Khadr's father - killed in Pakistan in 2003 - and brother are both accused of belonging to al-Qaeda.
Omar Khadr was captured after being wounded in an exchange of fire in eastern Afghanistan in July 2002.
New system
He is charged with throwing a grenade that killed one US soldier and wounded another.
The military also claims Mr Khadr spied on US troops in Afghanistan and planted land mines targeting American convoys.
The Canadian had faced similar charges under the first Guantanamo tribunal system.
But the US Supreme Court last year ruled the system unconstitutional and a new version was created by Congress.
Hicks, who last month pleaded guilty at the military court to a charge of providing material support for terrorism, was the first person to be tried under the new rules.
The US has said it plans to use the new system to prosecute about 80 of the remaining detainees, who number almost 400.
Human rights campaign group Amnesty International has condemned the tribunals as "shabby show trials" and demanded that detainees be tried under the regular US judicial system.