The Prince of Wales and the Duchess of Cornwall are set to visit victims of Hurricane Katrina in New Orleans in the latest stop of their eight-day US tour.
Charles said he was horrified by the destruction caused by Katrina
They will visit some of the areas worst hit in August when the storm struck the city in the state of Louisiana.
Ahead of the visit, the prince said he and his wife were "utterly horrified" by the destruction caused by Katrina, which killed about 1,200 people.
The couple will meet survivors and emergency workers during the visit.
About 80% of New Orleans was left underwater after the natural disaster, during which thousands of people were unable to evacuate or refused to leave their homes.
On Friday Charles and Camilla will spend a couple of hours in the southern city talking to survivors and emergency workers dedicated to cleaning up the devastation.
They will be given an opportunity to visit the Lower Ninth Ward Levee that was breached, sending water cascading into the historic city and causing huge swathes of it to be submerged underwater.
On Wednesday, Charles dedicated a $30,000 (£17,000) architecture prize to rebuild efforts in the nearby state of Mississippi during a visit to the National Building Museum in Washington.
The prince also revealed that his own Foundation for the Built Environment was involved in the state's redesign process.
And, in advance of his visit to New Orleans, he added: "We will have the opportunity to meet some of the brave and resilient people trying to rebuild their lives and to pay tribute to the astounding efforts of emergency workers.
"I only hope my foundation can play a small part in the work that is under way to begin the reconstruction."
The visit comes after the royal couple were entertained by President Bush at the White House at both a private family lunch and formal, black tie dinner.
The prince used a toast to his host to issue a thinly-veiled warning about the challenges and responsibilities before him, not least concerning the "crucial issues that face our planet".
During the dinner, the president told his guests that their visit was a reminder of the unique and enduring bond between the UK and US.
Before leaving Washington, Charles and his wife will lay a wreath at a World War II memorial and meet war veterans, before heading to the Folger Shakespeare Library to watch part of a children's performance of Much Ado About Nothing.
Last night the royals attended a reception at the residence of British Ambassador Sir David Manning. Earlier, Camilla gave her first formal speech abroad since marrying Charles.
Before speaking on osteoporosis at the National Institutes of Health, the Duchess caused widespread mirth after she narrowly avoided walking into a glass wall after a US surgeon attempted to lead her into a building.
Camilla, who saw the funny side, laughed and clapped a hand to her face, gesturing that she could have put her nose out of joint.
While in Washington, the newlyweds have also planted a tree at a school in a deprived area where they witnessed initiatives to tackle underachievement.
The couple began their eight-day US tour in New York, before moving on to Washington.
The trip is Prince Charles' and Camilla's first joint official overseas tour since they married.