The Colombian Supreme Court has authorised the extradition of a self-confessed drug-trafficker, Miguel Rodriguez Orejuela, to the US.
Orejuela's brother is already in the US
Mr Rodriguez Orejuela and his brother, Gilberto, founded the Cali Cartel, which dominated the global cocaine trade in the 1990s.
Gilberto Rodriguez Orejuela was sent to the US in December.
It is now up to Colombian President Alvaro Uribe to decide whether his brother should join him.
They both faces charges of continuing to run the cartel after being jailed in Colombia for drug-trafficking offences. Both deny the charges.
The Supreme Court also approved the extradition to the US of a suspected commander of the rebel group, the Farc.
The commander, Omaira Rojas, also known as Sonia, is believed to have run the Farc's finances in southern Colombia, but will also be prosecuted on drugs charges.
During the 1990s, the Cali drugs cartel is estimated to have controlled 80% of the global cocaine trade.
It was the richest and most powerful crime syndicate in the world, making profits of up to $8bn a year.