Peru's Interior Minister Javier Reategui has resigned over an army reservist uprising last week in which six people were killed.
More than 150 rebels took part in the uprising
The 150 nationalist reservists surrendered four days after seizing a remote police station in Andahuaylas.
Mr Reategui announced his resignation to Congress after being summoned to explain the government's response.
His departure is the latest blow to the deeply unpopular President Alejandro Toledo.
He is the eighth minister to leave Mr Toledo's government in three-and-a-half years.
It follows the resignation last May of the previous Interior Minister, Fernando Rospigliosi, after rural workers beat to death a local mayor who was accused of corruption.
Alejandro Toledo consistently gets around 10% approval ratings
"I am conscious that the political situation is polarised and that's precisely why I tell you that this morning I presented to the president of the republic my irrevocable resignation," Mr Reategui told congress.
"I leave with the peace of mind of a mission accomplished,"he said.
Political analysts say Peru's prime minister and defence minister could also be fired by congress for their failure to prevent the latest rebellion.
The leader of the nationalist uprising, Maj Antauro Humala, faces charges relating to kidnapping and the death of four policemen. Two of the rebels also died.
Maj Humala and his followers had demanded the resignation of the president, saying he had sold out the country to foreign influence, especially to traditional rival Chile.
The BBC's Hannah Hennessy says the uprising has raised fears of a new wave of political instability in remote parts of South America.