The plane came down in a densely populated area, ploughing through several buildings including two mosques before it came to a halt and burst into flames.
Terrified residents, screaming and sobbing, were reported to be searching for survivors in the shattered pieces of aircraft and crumbled homes.
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One local resident said people could be heard inside the wreckage screaming for help, but they perished because firefighters had no water and could not put out the fire.
Reports are also coming that one survivor was pulled out from the wreckage.
Older aircraft
Airport officials said the BAC 111-500 plane belonged to a private
Nigerian airline, EAS.
The plane had arrived safely in Kano from the central city of Jos, and had just set off for Lagos when it plunged to the ground.
There has not been a major air disaster in Nigeria since 1996 when 142 people died as a Boeing 727 plunged into a lagoon outside the commercial capital Lagos.
Nigeria deregulated its airline industry in the mid-1980s and about a dozen private companies, including EAS, sprang up to compete with state carrier Nigeria Airways.
Correspondents say there are concerns about the use of older aircraft by the private domestic carriers.
In April, the Nigerian Government announced a ban on the use of aircraft more than 22 years old, a move that triggered strong protests from private local airline operators.