Two 14-year-old girls last seen in a public house in Towcester on Saturday night are missing.
A Northamptonshire Police spokesman said they were particularly concerned for Rosemarie Swain and Samantha McMorrow, because of their age.
It is believed that they may have taken bags of clothing and other personal belongings with them from Degra House in the town.
They may have headed for London or Manchester where they have connections.
Rosemarie is of mixed race and 5ft 5in tall with a medium build. She has black, shoulder-length hair and brown eyes and speaks with a London accent.
Ponytail
When she was last seen she was wearing white, cropped trousers and a grey MacKenzie hooded top.
Rosemarie has connections in the Westminster and Maida Vale areas of London.
Samantha is 5ft tall and slightly built. She has dark brown hair, which she wears in a ponytail, and brown eyes. She speaks with a Manchester accent.
She was wearing denim clothing when she was last seen, but it is believed she has since changed her clothes.
She has connections in the M14 area of Manchester.