The Liberal Democrats kick off their party conference on a high following their spectacular by-election win in Brent East.
Jeremy will ask Menzies Campbell if the Lib Dems can make the big breakthrough
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Mrs Thatcher was prime minister when Labour last lost a seat at a by-election.
So how far can the party go and will it overtake the Tories as the main opposition party?
Find out why the Politics Show's Max Cotton thinks the answer lies with the trawler men of Cornwall.
Jeremy will be asking the Lib Dem's deputy leader Menzies Campbell if his party has really got what it takes to make the big breakthrough.
We'll also be looking at grey power in action.
Pensioners are up in arms at having to pay big rises in council tax when they're getting much smaller rises in their pensions. We'll be hearing about a growing revolt around the country.
And, David Thompson reports from America on the hot new campaigning techniques which have catapulted Howard Dean to the front of the race for the Democrat Presidential nomination.
Parties here are watching closely to see if this the way ahead for 21st century elections?
Plus, the latest on the Hutton inquiry and our regular MPs quiz.
The Politics Show with Jeremy Vine, on BBC One on Sunday at the later time of 1.30pm.
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