Pig organ research 'must continue'

Scientists want pig organ research to continue

Despite a UK Government report highlighting the potential dangers of pig organ transplants, researchers in the field still believe progress can be made.

Xenotransplantation, the use of organs from animals to replace those failing in humans, is seen by many as an important part of the solution to the chronic shortage of available donor organs.

Pig embryo clones could help remove viruses

However, the latest report from the government watchdog, the UK Xenotransplantation Interim Regulatory Authority, suggests that at the moment, animal-to-human transplants are too risky to contemplate.

Scientists fear that even tissues from specially bred and quarantined pigs may harbour unidentified viruses which could spread and cause disease in humans.

The report says that it is "prudent" to suggest that all xenotransplantation carries some risk.

The watchdog says that stem cell research may ultimately yield greater benefits.

'No zero risk'

However, scientists in the field refuse to be downbeat about the prospects for xenotransplantation. They believe that it may yet be possible to reduce the risks to humans to acceptable levels.

Professor Robin Weiss, of University College, London, UK, was one of the first to sound the alarm about the unknown risks of pig viruses.

Now, he says the pendulum of scientific opinion has swung too far against xenotransplantation.

He told BBC News Online: "There can never be a zero risk. But we are making progress. At the moment, I would have said that research was going along at quite a fast rate.

"There is a quite a lot of danger of infection even in human to human transplants - who knows whether members of the British population are incubating vCJD?"

Good and bad

He said that recent research suggested that anti-retroviral drugs developed for fighting HIV had showed some promise against the retroviruses carried by some pigs.

Xenotransplantation is certainly not finished

Dr Andrew George, Imperial College, London

He said: "It's possible we may even have a drug here to treat people if viruses are passed into them."

Another leading xenotransplantation researcher, Dr Andrew George, from Imperial College in London, was equally upbeat.

He told BBC News Online: "Clearly this is a problem, and more research is needed. But over the last year or so we have had both good news and bad news.

"But simply by doing this sort of research we learn an awful lot that can be used in other areas of medicine, so it should continue. Xenotransplantation is certainly not finished."

Pig clones

Another breakthrough made last year was the successful cloning of a pig.

This lays open the possibility that pig retroviruses, which are carried in the genetic makeup of the animal rather than being foreign "invaders", could be modified out of the pig clone.

However, it is still likely to be some time before the idea of whole-organ xenotransplantation can be contemplated.

There are also significant objections by animal rights campaigners, who condemn as unnatural the sterile living conditions which would have to enclose the donor pig throughout its life.

Two major players in UK xenotransplantation research, Imutran and PPL Therapeutics, are both ending their work in the UK.