Page last updated at 00:33 GMT, Saturday, 30 January 2010

Vaccine 'could cut HIV TB deaths'

Image of TB
The disease is caused by a bacterium

A vaccine could cut tuberculosis cases among HIV-positive Africans by almost two-fifths, a US study suggests.

The lung infection is the most common cause of death among HIV patients in the continent.

Journal Aids reports that Dartmouth Medical School research involving 2,000 people found significantly fewer TB cases in vaccinated patients.

An expert said the jab could be a cheaper option for countries struggling to find money for extra anti-HIV drugs.

TB is a massive problem - a third of people living with HIV in Africa are infected with it
Alvaro Bermejo, International HIV/Aids Alliance

HIV patients are particularly vulnerable to TB because their immune systems are compromised.

The vaccine works by boosting the immune responses of patients who have already been given the BCG vaccine earlier in life.

In itself, the BCG jab may offer some protection against TB, but this is far from certain, and protection may only last a few years after immunisation.

The researchers from Dartmouth Medical School in the US tested it among 2,000 HIV positive patients in Tanzania over a seven-year period.

The number of confirmed TB cases was 39% lower in the vaccinated group.

First vaccine

Professor Ford von Reyn, who led the study, said it was a "significant milestone".

One theory now suggests that patients could be given the booster jab as soon as they are diagnosed with HIV, before antiretroviral drugs are needed.

Alvaro Bermejo, executive director at the International HIV/Aids Alliance, said that the other way of fighting TB in HIV patients might be to give them antiretrovirals earlier, an expensive option compared with a vaccination programme.

He said: "This is a very important finding - it is the first time we are going to have a vaccine which is influential in preventing opportunistic infections in HIV patients.

"TB is a massive problem - a third of people living with HIV in Africa are infected with it.

"The reduction of 39% seen in Tanzania, although not fabulous, is a good result."

Print Sponsor

05 Aug 08 |  Health
Mobile units tackle TB in London
22 Mar 05 |  London
Doctors call for action over TB
03 Dec 04 |  Health
TB poses major threat to millions
26 Oct 04 |  Health

The BBC is not responsible for the content of external internet sites

Has China's housing bubble burst?
How the world's oldest clove tree defied an empire
Why Royal Ballet principal Sergei Polunin quit


Sign in

BBC navigation

Copyright © 2017 BBC. The BBC is not responsible for the content of external sites. Read more.

This page is best viewed in an up-to-date web browser with style sheets (CSS) enabled. While you will be able to view the content of this page in your current browser, you will not be able to get the full visual experience. Please consider upgrading your browser software or enabling style sheets (CSS) if you are able to do so.

Americas Africa Europe Middle East South Asia Asia Pacific