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Thursday, 19 July, 2001, 23:30 GMT 00:30 UK
Clot risks of newer pills confirmed
Women taking the pill
The safety debate over newer pills was sparked in 1995
Scientists have confirmed that women taking so-called "third generation" contraceptive pills are more likely to get potentially-fatal blood clots.

But experts stress women should not abandon their contraceptives and risk unwanted pregnancies, but seek medical advice and consider switching to another brand.

The debate first started in October 1995 when scientists warned that women taking the third generation pill were at greater risk of developing blood clots in the deep veins of the legs or the pelvis.

Women should not stop taking the pill because otherwise they risk getting pregnant and the risk of blood clots during pregnancy is much greater

Dr Ale Algra

Called venous thromboembolism (VTE), the clots can be fatal if they move inside the circulatory system and lodge in the lungs.

Scared by the news many women simply stopped taking their contraceptive and there was a boom in unwanted pregnancies and an 8% rise in the number of abortions (about 13,000).

Other experts later disputed the pill risk, saying it was much lower than first estimated.

But Dutch researchers have pooled research from 114 studies since 1995 and found that there is a 1.7 fold increased risk of clots from the third generation pills, compared to the older second generation.

These third generation, or newer pills, include Femodene, ED, Triadene, Minulet, Tri-minulet, Marvelon and Mercilon.


The risk of blood clots is higher among the newer pills because they contain the hormones desogestrel or gestodene, compared to levonorgestrel, which is used in the older brands.

The scientists also found that the risk was higher in women using the newer pills for the first time.

The authors said: "We crudely calculated that four deaths per million woman could be prevented by switching from third to second generation products.

"Although the risks are small, they should be considered when deciding which oral contraceptive to use."

Family history

Author Dr Ale Algra, associate professor of clinical epidemiology, at the University Medical Centre, Utrecht, said there was an increased risk.

But he said that women should not just stop taking the pill, but should discuss their contraception with their GP.

"You should not stop using contraceptives, but switch from third to second generation.

"This is not new news, but it is more robust.

"Women should not stop taking the pill because otherwise they risk getting pregnant and the risk of blood clots during pregnancy is much greater."

Women should use other contraceptives before stopping the pill

GP and womens' health and contraceptive specialist Dr Ann McPherson said GPs in the UK were aware of the risks and were more likely to prescribe women the second generation pills.

She said women being given the newer pills were informed of the risks.

A spokeswoman for the Family Planning Association said the new study reiterated the importance of careful prescribing.

"This does not tell us anything new, but it confirms that health professionals have to take a full medical and family history before prescribing," she said.

Professor Klim McPherson, an epidemiologist at the London School of Tropical Medicine and Hygiene, said the risks of the newer pills were well documented.

"I don't think there is any doubt it does increase the risk. It is quite clear this is the case and is why in this country women are not prescribed it much."

The research is published in the British Medical Journal.

See also:

10 Nov 00 | Health
Research spells out Pill risks
04 Apr 01 | Health
Pill to 'stop cancer'
16 Jun 00 | Health
Pill fears played down
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